NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Circ Res. 2021 May 28;128(11):1629-1641. doi: 10.1161/CIRCRESAHA.120.317046. Epub 2021 Apr 22.

Abstract

[Figure: see text].

Keywords: NAD; acetylation; cardiomyopathy; heart failure; mitochondria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Acyl-CoA Dehydrogenase / metabolism
  • Animals
  • Disease Models, Animal
  • Down-Regulation
  • Fatty Acids / metabolism
  • Heart Failure, Diastolic / therapy*
  • Humans
  • Ketone Oxidoreductases / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mitochondria, Heart / metabolism*
  • Mitochondrial Myopathies / metabolism
  • Mitochondrial Myopathies / therapy*
  • NAD / analysis
  • NAD / biosynthesis*
  • NAD / deficiency
  • NAD / genetics
  • Niacinamide / administration & dosage
  • Niacinamide / analogs & derivatives*
  • Oxidation-Reduction
  • Oxygen Consumption
  • Pyridinium Compounds / administration & dosage*
  • Sirtuin 3 / metabolism

Substances

  • Fatty Acids
  • Pyridinium Compounds
  • nicotinamide-beta-riboside
  • NAD
  • Niacinamide
  • Ketone Oxidoreductases
  • pyruvate dehydrogenase (NADP+)
  • Acyl-CoA Dehydrogenase
  • Sirtuin 3