Mobilization of stored hexachlorobenzene and p,p-dichlorodiphenyldichloroethylene during partial starvation in rats

Toxicol Lett. 1988 Jul;42(1):79-86. doi: 10.1016/0378-4274(88)90105-1.


Hexachlorobenzene (HCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) kinetics were compared in rats before, during and after partial starvation. Food restriction produced a drastic mobilization of the residues stored in the adipose tissue resulting in symptoms of neurotoxicity. The redistribution was reversible and did not produce a significant reduction in the chemicals body burden. HCB and p,p'-DDE, although both highly lipophilic, showed important differences in their blood transport and distribution pattern, with more HCB being transported by red blood cells and with a greater facility for HCB to reach the liver and the brain.

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Biological Transport
  • Body Weight
  • Chlorobenzenes / metabolism*
  • Feces / analysis
  • Female
  • Hexachlorobenzene / blood
  • Hexachlorobenzene / metabolism*
  • Lipid Mobilization
  • Rats
  • Rats, Inbred Strains
  • Starvation / metabolism*
  • Tissue Distribution


  • Chlorobenzenes
  • Hexachlorobenzene