SexX matters when it comes to pain

Neuron. 2021 Apr 21;109(8):1253-1254. doi: 10.1016/j.neuron.2021.04.004.


The neurobiology of sex differences in pain remain poorly understood. Yu et al. (2021) provide new insight by demonstrating that activation of dopaminergic projections from PAG to BNST provides substantial pain relief in male mice but virtually none in females.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dopaminergic Neurons
  • Dorsal Raphe Nucleus
  • Female
  • Male
  • Mice
  • Pain
  • Periaqueductal Gray*
  • Sex Characteristics*