Extreme conservation encodes the structural dynamics and function of 5' UTRs

Nat Genet. 2021 May;53(5):591-592. doi: 10.1038/s41588-021-00869-0.

Abstract

RNA is dynamic and can fold into multiple alternative conformations. A new study shows that the cell can control mRNA translation by regulating the stoichiometry of alternative RNA structures formed from extremely conserved 5’UTR sequences and that this control may contribute to embryonic development.

Publication types

  • Comment

MeSH terms

  • 3' Untranslated Regions
  • 5' Untranslated Regions / genetics
  • Animals
  • Evolution, Molecular*
  • Vertebrates*

Substances

  • 3' Untranslated Regions
  • 5' Untranslated Regions