Sleep disorders (insomnia, hypersomnia, parasomnias and breathing disturbances), hormonal changes and vasomotor symptoms are highly prevalent in peri and postmenopausal women. The aim of our study was to assess sleep quality, some sleep disturbances, depression and suffocation during postmenopausal. Data come from a cross-sectional study of 195 women, which was conducted at a University Hospital. Data related to sleep were assessed with the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Oviedo Sleep Questionnaire (OSQ) and Beck´s Inventory of Depression (BDIII). The hospital Ethical Committee granted their approval of this study. The mean PSQI score was 6.90½ 4.43. Up to 46.7% of participants had a PSQI > 5 (poor sleep quality). Snoring was reported by 13% of the patients (PSQI # 10 A). COS score was 17.57± 7. According to COS #1 all the subjects (100%) reported some degree of sleep dissatisfaction. Media of BDIII´s inventory of depression was 9.8 (½7.14), 41% of women reported depression. Correlation BDIII and PSQI was 0.00. We found that the level of dissatisfaction was elevated. One out of two women referred poor quality of sleep, requiring medical assistance. Poor sleep quality was associated with depression.