Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling

Alvin Qiu; Torsten O Nielsen

doi:10.1016/j.trecan.2021.03.002

Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling

Trends Cancer. 2021 Jun;7(6):482-483. doi: 10.1016/j.trecan.2021.03.002. Epub 2021 Apr 21.

Authors

Alvin Qiu¹, Torsten O Nielsen²

Affiliations

¹ Faculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
² Faculty of Medicine, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address: torsten@mail.ubc.ca.

PMID: 33893065
DOI: 10.1016/j.trecan.2021.03.002

Abstract

Synovial sarcoma is a soft tissue malignancy driven by the SS18-SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18-SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.

Keywords: SS18–SSX; epigenetics; immune exclusion; single-cell; synovial sarcoma.

Publication types

Comment

MeSH terms

Carcinogenesis
Epigenesis, Genetic
Humans
Oncogene Proteins, Fusion / genetics
Sarcoma, Synovial* / genetics

Substances

Oncogene Proteins, Fusion