Role of Zinc in Neonatal Sepsis

Indian J Pediatr. 2021 Apr 24. doi: 10.1007/s12098-021-03748-y. Online ahead of print.


Sepsis emerges as a complex clinical syndrome with activation of an innate host response to infections. Despite advancement in therapeutic approaches, infants with sepsis remain hospitalized for longer durations and it remains to be a major health problem in today's world. Zinc as a trace element, has the potential to improve the host's defence mechanism against various pathogenic diseases. During sepsis, a redistribution of zinc from serum into the liver has been observed and earlier studies imply a correlation between serum zinc levels and the outcome of sepsis. Zinc also appears to have a potential to be used as a biomarker of sepsis outcome. There are only few reports available to show the efficacy of zinc supplements in the management of neonatal sepsis.

Keywords: Immunity; Neonatal sepsis; Serum zinc; Zinc homeostasis; Zinc supplementation.

Publication types

  • Review