ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype

J H von der Thüsen; D W Dumoulin; A P W M Maat; J Wolf; A H Sadeghi; J G J V Aerts; R Cornelissen

doi:10.1016/j.lungcan.2021.04.015

ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype

Lung Cancer. 2021 Jun:156:72-75. doi: 10.1016/j.lungcan.2021.04.015. Epub 2021 Apr 16.

Authors

J H von der Thüsen¹, D W Dumoulin², A P W M Maat³, J Wolf⁴, A H Sadeghi³, J G J V Aerts², R Cornelissen²

Affiliations

¹ Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands. Electronic address: j.vonderthusen@erasmusmc.nl.
² Department of Pulmonary Medicine, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
³ Department of Thoracic Surgery Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
⁴ Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

PMID: 33895680
DOI: 10.1016/j.lungcan.2021.04.015

Abstract

Introduction: NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered.

Methods: We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS.

Results: On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma.

Conclusions: This entity represents a novel subtype of non-small cell lung cancer, which we would like to term 'ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma'.

Keywords: Adenocarcinoma; ETV6-NTRK3; NSCLC; NTRK.

Publication types

Case Reports

MeSH terms

Adenocarcinoma* / genetics
Carcinoma, Non-Small-Cell Lung* / genetics
Humans
Lung Neoplasms* / genetics
Middle Aged
Oncogene Proteins, Fusion / genetics
Salivary Gland Neoplasms*
Salivary Glands

Substances

ETV6-NTRK3 fusion protein, human
Oncogene Proteins, Fusion