An antineuronal autoantibody in paraneoplastic opsoclonus

Ann Neurol. 1988 May;23(5):528-31. doi: 10.1002/ana.410230518.

Abstract

Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53- to 61-kDa and 79- to 84-kDa antigens in immunoblots of neurons. Antineuronal antibodies were not found in other patients with paraneoplastic opsoclonus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / blood*
  • Breast Neoplasms / complications
  • Breast Neoplasms / immunology*
  • Carcinoma / complications
  • Carcinoma / immunology*
  • Cerebellum / immunology*
  • Eye Movements*
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Molecular Weight
  • Neurons / immunology
  • Paraneoplastic Syndromes / immunology*

Substances

  • Autoantibodies