Reductions in acetylcholine and nicotine binding in several degenerative diseases

Arch Neurol. 1988 Jul;45(7):722-4. doi: 10.1001/archneur.1988.00520310028012.


Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylcholine / metabolism*
  • Aged
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / metabolism*
  • Cerebral Cortex / metabolism
  • Choline O-Acetyltransferase / metabolism
  • Humans
  • Nicotine / metabolism*
  • Parkinson Disease / enzymology
  • Parkinson Disease / metabolism*
  • Receptors, Nicotinic / metabolism
  • Supranuclear Palsy, Progressive / enzymology
  • Supranuclear Palsy, Progressive / metabolism*


  • Receptors, Nicotinic
  • Nicotine
  • Choline O-Acetyltransferase
  • Acetylcholine