Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function

Circ Res. 2021 Jun 25;129(1):63-77. doi: 10.1161/CIRCRESAHA.120.318501. Epub 2021 Apr 27.

Abstract

[Figure: see text].

Keywords: arteries; endothelium; homeostasis; ischemia; transcription factor; vasodilation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta / metabolism
  • Aorta / physiopathology
  • Calcium / metabolism
  • Calcium Signaling
  • Cells, Cultured
  • Collateral Circulation
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Disease Models, Animal
  • Endothelial Cells / metabolism*
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Femoral Artery / metabolism*
  • Femoral Artery / physiopathology
  • Hindlimb / blood supply*
  • Ischemia / genetics
  • Ischemia / metabolism*
  • Ischemia / physiopathology
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Smooth, Vascular / metabolism
  • Muscle, Smooth, Vascular / physiopathology
  • Myocytes, Smooth Muscle / metabolism
  • Neovascularization, Physiologic*
  • Regional Blood Flow
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • Prdm16 protein, mouse
  • Transcription Factors
  • Calcium