Red cell antibodies in thalassemia hemoglobinopathy patients

P Tardtong; P Ratanasirivanich; P Chiewsilp; P Hathirat

Red cell antibodies in thalassemia hemoglobinopathy patients

Birth Defects Orig Artic Ser. 1988;23(5B):287-9.

Authors

P Tardtong¹, P Ratanasirivanich, P Chiewsilp, P Hathirat

Affiliation

¹ Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

PMID: 3390554

Abstract

One hundred sixty-four previously transfused patients with T/H disease received one to 136 transfusions with an average of 14.65. Immunization to red blood cell occurred in 14 patients (8.5%). Among these, 11 patients had alloantibody, one patient had autoimmune antibody, and two patients had both alloantibody and autoimmune antibody. The naturally occurring antibody (anti-Leb) was observed in pretransfused blood samples of two patients (1.2%). Most red cell immunization seemed to occur in the early period of blood transfusion.

MeSH terms

Child, Preschool
Erythrocytes / immunology*
Hemoglobinopathies / immunology*
Humans
Isoantibodies / analysis*
Retrospective Studies
Thalassemia / immunology*
Transfusion Reaction

Substances

Isoantibodies