Characterization of the Rothia spp. and their role in human clinical infections

Infect Genet Evol. 2021 Sep;93:104877. doi: 10.1016/j.meegid.2021.104877. Epub 2021 Apr 24.


The genus Rothia are emerging as opportunistic pathogens associated with various infections in immunocompromised and immunocompetent individuals. This review describes the taxonomy, cell wall structure, pathogenesis, phenotypic and molecular characteristics, clinical diseases, treatment and, as well as, the related genera that may be misidentified by Rothia species.

Keywords: Infection; Opportunistic pathogen; Rothia; Taxonomy; Treatment.

Publication types

  • Review

MeSH terms

  • Gram-Positive Bacterial Infections* / microbiology
  • Gram-Positive Bacterial Infections* / therapy
  • Humans
  • Immunocompromised Host
  • Micrococcaceae* / classification
  • Micrococcaceae* / cytology
  • Micrococcaceae* / genetics
  • Micrococcaceae* / physiology