Takayasu arteritis in an adolescent with Crohn's disease

Rheumatol Int. 2022 Mar;42(3):563-570. doi: 10.1007/s00296-021-04869-5. Epub 2021 Apr 27.


Crohn's disease (CD) and Takayasu arteritis (TA) are two distinct clinical entities. Τhe likelihood of both diseases coexisting is low, and although CD co-occurs with all types of vasculitis, TA is the most common subtype. Herein, the case of a 15-year-old female, diagnosed with TA following an initial diagnosis of CD, is reported. A review of the literature, including a systemic review of the case reports and case series of children and adolescents up to the age of 21, with both CD and TA, follows the case description. In total, 28 cases of TA and CD were retrieved. The median age of patients was 14.8 years, they were mostly females (72%) and the median time between the two diagnoses was 3.7 years. In the majority of cases, CD was diagnosed first and TA followed. Computed tomography angiography and magnetic resonance angiography were the preferred imaging modalities to assist diagnosis.

Keywords: Adolescence; Child; Crohn’s disease; TNF blockers; Takayasu arteritis; Vasculitis; pediatric.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Child
  • Crohn Disease / complications
  • Crohn Disease / diagnostic imaging
  • Crohn Disease / pathology*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Takayasu Arteritis / complications
  • Takayasu Arteritis / diagnostic imaging
  • Takayasu Arteritis / pathology*
  • Tomography, X-Ray Computed