Identification of hippocampal cortical microinfarcts on postmortem 3-T magnetic resonance imaging

Neuroradiology. 2021 Sep;63(9):1569-1573. doi: 10.1007/s00234-021-02717-8. Epub 2021 Apr 28.


Cortical microinfarcts (CMI) are increasingly recognized in the neurological community as a biomarker related to cognitive impairment and dementia. If their radiological depiction has been largely described in experimental settings using ultra-high-field magnetic resonance imaging (MRI), less is known about their visibility on routinely used 3-T MRI. In this radiologic-pathologic correlation study, using 3-T post-mortem MRI, we searched for hippocampal CMI, in a double-blinded fashion, and found that only 4/36, or 11%, were clearly demonstrated on both radiological and histopathological exams.

Keywords: 3-T post-mortem MRI; Cerebral microinfarcts; Dementia; Hippocampus; Histopathology.

MeSH terms

  • Cerebral Infarction*
  • Hippocampus / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging*