Making sense of associations between type 2 diabetes, metformin, and breast cancer risk

Br J Cancer. 2021 Sep;125(7):909-910. doi: 10.1038/s41416-021-01372-3. Epub 2021 Apr 28.

Abstract

The relationship between type 2 diabetes (T2D), metformin, and breast cancer is complex. T2D may increase risk, but metformin used as first-line treatment of T2D may decrease breast cancer risk. This comment explores efforts to disentangle effects of T2D and metformin use on breast cancer risk in a prospective study.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / prevention & control
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Female
  • Humans
  • Metformin / therapeutic use*
  • Prospective Studies
  • Receptors, Estrogen / metabolism

Substances

  • Receptors, Estrogen
  • Metformin