Brunner's Gland Hamartoma of the Duodenum: A Literature Review

Adv Ther. 2021 Jun;38(6):2779-2794. doi: 10.1007/s12325-021-01750-6. Epub 2021 Apr 29.


Brunner's gland hamartoma is a benign tumor of the duodenum, but has malignant potential with a very low risk of progression into adenocarcinoma. It is uncommon with a frequency of less than 1.0% among the primary tumors of the small intestine. In addition, its clinical manifestations are nonspecific, etiology remains unclear, and treatment strategy needs to be further refined. This literature review mainly discusses the epidemiology, clinical features, possible etiology and pathogenesis, diagnostic methods, malignant potential, treatment, and prognosis of Brunner's gland hamartoma.

Keywords: Brunner’s gland; Duodenum; Etiology; Hamartoma; Hyperplasia.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma*
  • Brunner Glands* / surgery
  • Duodenum / surgery
  • Hamartoma* / diagnosis
  • Hamartoma* / surgery
  • Humans