Current Therapeutic Options in Aortic Stenosis

Circ Res. 2021 Apr 30;128(9):1398-1417. doi: 10.1161/CIRCRESAHA.121.318040. Epub 2021 Apr 29.


Aortic stenosis is the most common valvular disease requiring valve replacement. Valve replacement therapies have undergone progressive evolution since the 1960s. Over the last 20 years, transcatheter aortic valve replacement has radically transformed the care of aortic stenosis, such that it is now the treatment of choice for many, particularly elderly, patients. This review provides an overview of the pathophysiology, presentation, diagnosis, indications for intervention, and current therapeutic options for aortic stenosis.

Keywords: aortic valve; aortic valve stenosis; coronary artery disease; heart disease; transcatheter aortic valve replacement.