Overview of SARS-CoV-2 infection in adults living with HIV

Lancet HIV. 2021 May;8(5):e294-e305. doi: 10.1016/S2352-3018(21)00070-9.


Around 2·5 million deaths and more than 110 million COVID-19 cases have been reported globally. Although it initially appeared that HIV infection was not a risk factor for COVID-19 or more severe disease, more recent large studies suggest that people living with HIV (particularly with low CD4 cell counts or untreated HIV infection) might have a more severe clinical course than those who are HIV-negative. Moreover, the COVID-19 pandemic has disrupted HIV prevention and treatment services worldwide, creating huge challenges to the continuity of essential activities. We have reviewed the most relevant features of COVID-19 in people living with HIV and highlighted topics where further research is required.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • COVID-19 / complications*
  • COVID-19 / epidemiology
  • COVID-19 / immunology
  • COVID-19 Vaccines / immunology
  • COVID-19 Vaccines / standards
  • Comorbidity
  • Disease Progression
  • Female
  • HIV Infections / complications*
  • HIV Infections / epidemiology
  • HIV Infections / immunology
  • Humans
  • Male
  • Prognosis
  • SARS-CoV-2* / immunology


  • COVID-19 Vaccines