Abstract
Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro and in vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through near-infrared optical imaging in cells and in mice. They display anti-proliferative properties in micromolar range against human and murine cancer cell lines (4T1, MDA-MB-231, CT26, and SW480). Moreover, the injection of the most promising theranostic agent in CT26 tumor-bearing BALB/c mice induced a significant anti-cancer activity.
Keywords:
Gold complexes; NIR fluorescence; Theranostics; aza-BODIPY; cancer; optical imaging.
Copyright © 2021 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Aza Compounds / chemistry
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Aza Compounds / pharmacology
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Boron Compounds / chemistry
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Boron Compounds / pharmacology
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacology*
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Gold / chemistry
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Gold / pharmacology
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Humans
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Infrared Rays
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Mice
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Mice, Inbred BALB C
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Molecular Structure
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Neoplasms, Experimental / drug therapy
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Neoplasms, Experimental / metabolism
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Neoplasms, Experimental / pathology
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Optical Imaging
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
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Antineoplastic Agents
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Aza Compounds
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Boron Compounds
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Coordination Complexes
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Fluorescent Dyes
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Gold