Allopurinol kinetics after massive overdosage

Hum Toxicol. 1988 May;7(3):293-4. doi: 10.1177/096032718800700313.

Abstract

A 15-year-old girl with normal renal function took 75 tablets of allopurinol 300 mg. She did not suffer any ill-effects. Samples obtained over 84 h showed prolonged elimination of allopurinol, with a half-life of 3.6 h, and oxipurinol, with a half-life of 26 h.

MeSH terms

  • Adolescent
  • Allopurinol / blood
  • Allopurinol / pharmacokinetics
  • Allopurinol / poisoning*
  • Allopurinol / urine
  • Female
  • Half-Life
  • Humans
  • Oxypurinol / analysis
  • Oxypurinol / blood
  • Uric Acid / blood
  • Xanthine
  • Xanthines / blood

Substances

  • Xanthines
  • Xanthine
  • Uric Acid
  • Allopurinol
  • Oxypurinol