JNK Pathway in CNS Pathologies

Int J Mol Sci. 2021 Apr 9;22(8):3883. doi: 10.3390/ijms22083883.


The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals. Beside the stress response, the JNK pathway is involved in a series of vital regulatory mechanisms during development and adulthood that are critical to maintain tissue homeostasis. These mechanisms include the regulation of apoptosis, growth, proliferation, differentiation, migration and invasion. The JNK pathway has a diverse functionality and cell-tissue specificity, and has emerged as a key player in regeneration, tumorigenesis and other pathologies. The JNK pathway is highly active in the central nervous system (CNS), and plays a central role when cells need to cope with pathophysiological insults during development and adulthood. Here, we review the implications of the JNK pathway in pathologies of the CNS. More specifically, we discuss some newly identified examples and mechanisms of JNK-driven tumor progression in glioblastoma, regeneration/repair after an injury, neurodegeneration and neuronal cell death. All these new discoveries support the central role of JNK in CNS pathologies and reinforce the idea of JNK as potential target to reduce their detrimental effects.

Keywords: CNS injuries; MAP kinase; cell signalling; glioblastoma; neurodegenerative disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Central Nervous System / metabolism*
  • Central Nervous System Diseases / diagnosis
  • Central Nervous System Diseases / etiology*
  • Central Nervous System Diseases / metabolism*
  • Disease Susceptibility*
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism*
  • MAP Kinase Signaling System*


  • Biomarkers
  • JNK Mitogen-Activated Protein Kinases