Grafting Dendrons onto Pillar[5]Arene Scaffolds

Molecules. 2021 Apr 18;26(8):2358. doi: 10.3390/molecules26082358.

Abstract

With their ten peripheral substituents, pillar[5]arenes are attractive compact scaffolds for the construction of nanomaterials with a controlled number of functional groups distributed around the macrocyclic core. This review paper is focused on the functionalization of pillar[5]arene derivatives with small dendrons to generate dendrimer-like nanomaterials and bioactive compounds. Examples include non-viral gene vectors, bioactive glycoclusters, and liquid-crystalline materials.

Keywords: dendrimers; glycoclusters; liquid crystals; pillar[5]arene; transfection.

Publication types

  • Review

MeSH terms

  • Calixarenes / chemistry*
  • Calixarenes / pharmacology
  • Dendrimers / chemistry*
  • Dendrimers / pharmacology
  • Genetic Vectors / chemistry*
  • Genetic Vectors / genetics
  • Humans
  • Models, Molecular
  • Nanostructures / chemistry*
  • Tissue Scaffolds / chemistry

Substances

  • Dendrimers
  • pillar(5)arene
  • Calixarenes