The Usefulness of Lymphadenectomy in Bladder Cancer-Current Status

Medicina (Kaunas). 2021 Apr 25;57(5):415. doi: 10.3390/medicina57050415.


The purpose of this review is to present the current status of lymph node dissection (LND) during radical cystectomy in patients with bladder cancer (BCa). Despite the growing body of evidence of LND utility at the time of radical cystectomy (RC) in high-risk nonmuscle-invasive and muscle-invasive BCa (MIBC), therapeutic and prognostic value and optimal extent of LND remain unsolved issues. Recently published results of the first prospective, a randomized trial assessing the therapeutic benefit of extended versus limited LND during RC, failed to demonstrate survival improvement with the extended template. Although LND is the most accurate staging procedure, the direct therapeutic effect is still not evident from the current literature, limiting the possibility of establishing clear recommendations. This indicates the need for robust and adequately powered clinical trials.

Keywords: bladder cancer; lymph node dissection; lymphadenectomy; staging; surgery.

Publication types

  • Review

MeSH terms

  • Cystectomy
  • Humans
  • Lymph Node Excision
  • Neoplasm Staging
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Urinary Bladder Neoplasms* / surgery