Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Cells. 2021 Apr 20;10(4):957. doi: 10.3390/cells10040957.

Abstract

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer's disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.

Keywords: Alzheimer’s disease; TREM2; inflammation; microglia; neurodegenerative diseases; neuroinflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism
  • Alzheimer Disease / pathology*
  • Animals
  • Embryonic Development*
  • Homeostasis*
  • Humans
  • Microglia / immunology
  • Microglia / metabolism*
  • Receptors, Cytoplasmic and Nuclear / agonists
  • Receptors, Cytoplasmic and Nuclear / metabolism

Substances

  • Receptors, Cytoplasmic and Nuclear