Reprogramming: Emerging Strategies to Rejuvenate Aging Cells and Tissues

Int J Mol Sci. 2021 Apr 13;22(8):3990. doi: 10.3390/ijms22083990.


Aging is associated with a progressive and functional decline of all tissues and a striking increase in many "age-related diseases". Although aging has long been considered an inevitable process, strategies to delay and potentially even reverse the aging process have recently been developed. Here, we review emerging rejuvenation strategies that are based on reprogramming toward pluripotency. Some of these approaches may eventually lead to medical applications to improve healthspan and longevity.

Keywords: aging; epigenetics; iPSC; reprogramming; senescence; stem cells.

Publication types

  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Cellular Reprogramming*
  • Cellular Senescence*
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Regenerative Medicine
  • Rejuvenation*