Advanced Ovarian Cancer during Pregnancy. Tumour Evolution Analysis and Treatment Approach

Medicina (Kaunas). 2021 Apr 28;57(5):426. doi: 10.3390/medicina57050426.


Background: The possible presence of malignant adnexal mass should be considered during pregnancy. For this reason, it is important to keep in mind such possibility while performing routine obstetric ultrasounds to diagnose asymptomatic ovarian cancer in the early stages.

Case presentation: 27-year-old pregnant patient with a known adnexal tumour occurring at week 20 and enlarged supraclavicular lymph nodes of 3 cm size who was diagnosed with metastases from low-grade papillary serous ovarian carcinoma. The patient, obstetricians, neonatologists and oncologists agreed on initiating neoadjuvant chemotherapy and performing an elective C-section at week 34. She gave birth to a female infant weighing 2040 g who is currently in good health, and continues receiving follow-up care by a medical oncologist.

Conclusions: An early diagnosis of gynaecologic malignancies during pregnancy is of critical importance because, although they are very rare, managing and treating carcinomas at an early stage allow us to increase maternal and fetal well-being and to offer more alternatives to our patients.

Keywords: cancer; chemoradiation; ovarian cancer; pregnancy; surgery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma*
  • Cystadenocarcinoma, Serous*
  • Female
  • Humans
  • Lymph Nodes
  • Neoadjuvant Therapy
  • Ovarian Neoplasms* / diagnostic imaging
  • Ovarian Neoplasms* / drug therapy
  • Pregnancy