Analysis of Recent Literature on Lung Volume Reduction Surgery

Thorac Surg Clin. 2021 May;31(2):119-128. doi: 10.1016/j.thorsurg.2021.01.003.


Publication of the National Emphysema Treatment Trial (NETT) in 2003 established lung volume reduction surgery (LVRS) as a viable treatment of select patients with moderate to severe emphysema, and the only intervention since the availability of ambulatory supplemental oxygen to improve survival. Despite these findings, surgical treatment has been underused in part because of concern for high morbidity and mortality. This article reviews recent literature generated since the original NETT publication, focusing on physiologic implications of LVRS, recent data regarding the safety and durability of LVRS, and patient selection and extension of NETT criteria to other patient populations.

Keywords: COPD; Emphysema; Lung volume reduction surgery.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • Humans
  • Inflammation / metabolism*
  • Patient Safety
  • Patient Selection
  • Pneumonectomy / methods*
  • Pulmonary Disease, Chronic Obstructive / surgery*
  • Pulmonary Emphysema / mortality
  • Pulmonary Emphysema / surgery*
  • Pulmonary Medicine / trends
  • Quality of Life
  • Risk
  • Treatment Outcome
  • United States