Cancer Physical Hallmarks as New Targets for Improved Immunotherapy

Hui Guo; Tian Zhang; Yang Yu; Feng Xu

doi:10.1016/j.tcb.2021.03.011

Cancer Physical Hallmarks as New Targets for Improved Immunotherapy

Trends Cell Biol. 2021 Jul;31(7):520-524. doi: 10.1016/j.tcb.2021.03.011. Epub 2021 Apr 27.

Authors

Hui Guo¹, Tian Zhang², Yang Yu², Feng Xu³

Affiliations

¹ Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China. Electronic address: guohui@xjtufh.edu.cn.
² Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, P.R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China.
³ Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, P.R. China; MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China. Electronic address: fengxu@mail.xjtu.edu.cn.

PMID: 33926772
DOI: 10.1016/j.tcb.2021.03.011

Abstract

A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.

Keywords: cancer immunotherapy; immune-engineering; immunophenotype; mechano-nanomedicine; physical microenvironment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immunotherapy*
Neoplasms* / therapy
Tumor Microenvironment