Single nucleotide polymorphism in CD36: Correlation to peptide YY levels in obese and non-obese adults

Clin Nutr. 2021 May;40(5):2707-2715. doi: 10.1016/j.clnu.2021.02.044. Epub 2021 Mar 6.


Background & aims: Human beings are often driven to exhibit dietary preference according to their hedonic characteristics. Though previous studies proposed that the fat taste preference of an obese individual was associated with BMI, the perception of fat taste differs for every individual. The genetic variation among populations in taste receptor genes such as CD36 may be a contributing factor for this difference. Satiety peptides can also play a role in the regulation of fat taste perception. Generally, this hormone helps us to feel the sense of satiety.

Methods: We have analysed the relationship among oro-gustatory perception of dietary lipids, salivary peptide-YY and genetic polymorphism in CD36. Oral fatty acid sensitivity analysis was performed by alternative forced choice method. Salivary peptide-YY concentration was analysed by ELISA and single nucleotide polymorphism (SNP) in CD36 gene was determined by Real-Time PCR experiments.

Results: We observed that the SNP at rs1761667 of CD36 and oral detection threshold for linoleic acid (LA) are associated with choice of food, lipid profiles, peptide-YY as well as adiposity parameters in obese population. Obese peoples had significantly low levels of peptide YY than people with BMI less than 25. These factors possibly play a role in preference for energy rich diets, development of obesity and associated complications.

Conclusion: This study provides a solid foundation for understanding the alterations in the dietary fat intake and levels of peptide-YY, which are associated with polymorphism in fat taste receptor. This is the first report that shows a significant relationship between the satiety hormone level, SNP in CD36 gene and oral fat detection threshold in human subjects.

Keywords: CD36; Fat taste; Obesity; Peptide-YY; Polymorphism; rs1761667.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD36 Antigens / genetics*
  • Gene Expression Regulation
  • Genetic Variation
  • Humans
  • Obesity / blood
  • Obesity / genetics
  • Obesity / metabolism*
  • Peptide YY / blood*
  • Peptide YY / genetics
  • Peptide YY / metabolism
  • Polymorphism, Single Nucleotide*


  • CD36 Antigens
  • Peptide YY