Mineralocorticoid and Estrogen Receptors in Endothelial Cells Coordinately Regulate Microvascular Function in Obese Female Mice

Hypertension. 2021 Jun;77(6):2117-2126. doi: 10.1161/HYPERTENSIONAHA.120.16911. Epub 2021 May 3.

Abstract

[Figure: see text].

Keywords: endothelium; estrogen receptor; mineralocorticoid receptor; obesity; vasodilation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Estrogen Receptor Antagonists / pharmacology
  • Estrogens / pharmacology
  • Female
  • Fulvestrant / pharmacology
  • Mice
  • Mice, Knockout
  • Mice, Obese
  • Microvessels / drug effects
  • Microvessels / metabolism*
  • Microvessels / physiopathology
  • Nitric Oxide Synthase Type III / metabolism
  • Obesity / genetics
  • Obesity / metabolism*
  • Obesity / physiopathology
  • Phosphorylation / drug effects
  • Receptors, Estrogen / metabolism*
  • Receptors, Mineralocorticoid / genetics
  • Receptors, Mineralocorticoid / metabolism*
  • Signal Transduction / drug effects

Substances

  • Estrogen Receptor Antagonists
  • Estrogens
  • Receptors, Estrogen
  • Receptors, Mineralocorticoid
  • Fulvestrant
  • Nitric Oxide Synthase Type III