Pertussis vaccine effectiveness and duration of protection - A systematic review and meta-analysis

Krista Wilkinson; Christiaan H Righolt; Lawrence J Elliott; Sergio Fanella; Salaheddin M Mahmud

doi:10.1016/j.vaccine.2021.04.032

Pertussis vaccine effectiveness and duration of protection - A systematic review and meta-analysis

Vaccine. 2021 May 27;39(23):3120-3130. doi: 10.1016/j.vaccine.2021.04.032. Epub 2021 Apr 30.

Authors

Krista Wilkinson¹, Christiaan H Righolt², Lawrence J Elliott³, Sergio Fanella⁴, Salaheddin M Mahmud⁵

Affiliations

¹ Vaccine and Drug Evaluation Centre, Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
² Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
³ Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
⁴ Department of Pediatric Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada.
⁵ Vaccine and Drug Evaluation Centre, Department of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Electronic address: Salah.Mahmud@gmail.com.

PMID: 33934917
DOI: 10.1016/j.vaccine.2021.04.032

Abstract

A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (aP) pertussis vaccines and conducted a formal meta-analysis using random effects models. Evidence continues to suggest that receipt of any pertussis vaccine confers protection in the short-term against disease although this protection wanes rapidly for aP vaccine. We detected significant heterogeneity in pooled estimates due, in part, to factors such as bias and confounding which may be mitigated by study design. Our review of possible sources of heterogeneity may help interpretation of other VE studies and aid design decisions in future pertussis VE research.

Keywords: Bordetella pertussis; Pertussis vaccine; Systematic review and meta-analysis; Vaccine effectiveness; Whooping cough.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Biomedical Research*
Humans
Pertussis Vaccine
Research Design
Whooping Cough* / prevention & control

Substances

Pertussis Vaccine