Plasma Short-Chain Fatty Acids Differences in Multiple System Atrophy from Parkinson's Disease

J Parkinsons Dis. 2021;11(3):1167-1176. doi: 10.3233/JPD-212604.

Abstract

Background: Multiple system atrophy (MSA) and Parkinson's disease (PD) have overlapping symptoms, making diagnosis challenging. Short-chain fatty acids (SCFAs) are produced exclusively by gut microbiota and were reduced in feces of MSA patients. However, plasma SCFA concentrations in MSA patients have not been investigated.

Objective: We aimed to investigate the plasma SCFAs in MSA patients and to identify the potential differential diagnostic ability.

Methods: Plasma SCFA were measured in 25 MSA patients, 46 healthy controls, and 46 PD patients using gas chromatography-mass spectrometry. Demographic and clinical characteristics of the participants were evaluated.

Results: Acetic acid concentration was lower in MSA patients than in healthy controls. Acetic acid and propionic acid concentrations were lower in MSA and MSA with predominant parkinsonism (MSA-P) patients than in PD patients. A receiver operating characteristic curve (ROC) analysis revealed reduced acetic acid concentration discriminated MSA patients from healthy controls with 76% specificity but only 57% sensitivity and an area under the curve (AUC) of 0.68 (95% confidence interval (CI): 0.55-0.81). Combined acetic acid and propionic acid concentrations discriminated MSA patients from PD patients with an AUC of 0.82 (95% CI: 0.71-0.93), 84% specificity and 76% sensitivity. Especially, with combined acetic acid and propionic acid concentrations, MSA-P patients were separated from PD patients with an AUC of 0.89 (95% CI: 0.80-0.97), 91% specificity and 80% sensitivity.

Conclusion: Plasma SCFAs were decreased in MSA patients. The combined acetic acid and propionic acid concentrations may be a potential biomarker for differentiating MSA patients from PD patients.

Keywords: Multiple system atrophy; Parkinson’s disease; biomarker; short-chain fatty acids.

MeSH terms

  • Diagnosis, Differential
  • Fatty Acids, Volatile
  • Humans
  • Multiple System Atrophy* / diagnosis
  • Parkinson Disease* / diagnosis
  • Propionates

Substances

  • Fatty Acids, Volatile
  • Propionates