Recent advances in polysaccharides from Lentinus edodes (Berk.): Isolation, structures and bioactivities

Food Chem. 2021 Oct 1:358:129883. doi: 10.1016/j.foodchem.2021.129883. Epub 2021 Apr 20.


Lentinus edodes, an important edible mushroom cultivated in East Asia for thousands of years, has been widely used as food and medicinal ingredient worldwide. Modern phytochemistry studies have demonstrated that L. edodes is very rich in bioactive polysaccharides, especially the β-glucans. Over the past two decades, the isolation, chemical properties, and bioactivities of polysaccharides from fruiting bodies, mycelium and fermentation broth of L. edodes have been drawing much attention from scholars around the world. It has been demonstrated that L. edodes polysaccharides possess various remarkable biological activities, including anti-oxidant, anti-tumor, anti-aging, anti-inflammation, immunomodulatory, antiviral, and hepatoprotection effects. This review summarizes the recent development of polysaccharides from L. edodes including the isolation methods, structural features, bioactivities and mechanisms, and their structure-activity relationship, which can provide useful research underpinnings and update information for their further application as therapeutic agents and functional foods.

Keywords: Antitumor mechanism; Lentinus edodes; Polysaccharides; Structure–activity relationship; β-Glucan.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Functional Food
  • Fungal Polysaccharides / chemistry*
  • Fungal Polysaccharides / isolation & purification
  • Fungal Polysaccharides / pharmacology*
  • Humans
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology
  • Mycelium / chemistry
  • Shiitake Mushrooms / chemistry*
  • Structure-Activity Relationship
  • beta-Glucans / chemistry
  • beta-Glucans / pharmacology


  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Antioxidants
  • Antiviral Agents
  • Fungal Polysaccharides
  • Immunologic Factors
  • beta-Glucans