Modeling myelin: A toolkit for exploring myelin's mysteries in vitro

Madeline H Cooper; J Bradley Zuchero

doi:10.1016/j.devcel.2021.04.015

Modeling myelin: A toolkit for exploring myelin's mysteries in vitro

Dev Cell. 2021 May 3;56(9):1215-1217. doi: 10.1016/j.devcel.2021.04.015.

Authors

Madeline H Cooper¹, J Bradley Zuchero²

Affiliations

¹ Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: mhcooper@stanford.edu.
² Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: zuchero@stanford.edu.

PMID: 33945781
DOI: 10.1016/j.devcel.2021.04.015

Abstract

In the myelin field, there is a lack of reliable in vitro tools to study myelination, especially using human cells. In this issue of Developmental Cell, James et al. present a guide to generating human iPSC-derived "myelinoids"-3D models of myelination that reliably achieve mature myelin formation.

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MeSH terms

Humans
Induced Pluripotent Stem Cells*
Myelin Sheath*