Participation of aldehyde dehydrogenase in the oxidative deamination pathway of histamine and putrescine

Agents Actions. 1988 Apr;23(3-4):311-3. doi: 10.1007/BF02142573.

Abstract

Some guinea pig tissue homogenates have shown the ability to catabolize, in vitro, imidazoloacetaldehyde (ImAAL) and gamma-aminobutyraldehyde (GABAL) via NAD-dependent aldehyde dehydrogenase (ALDH, EC 1.2.1.3). The liver, kidney, small intestine and gastric mucosa are the richest sources of ALDH activity towards ImAAL. The liver, kidney, small intestine and pancreas also show ALDH activity with GABAL as a substrate. All tissues tested have shown low Km and high Km ALDH activity with propionaldehyde as substrate. The guinea pig liver ALDH which is able to oxidize ImAAL and GABAL is located exclusively in the cytoplasm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Dehydrogenase / metabolism*
  • Aldehydes / metabolism
  • Animals
  • Deamination
  • Guinea Pigs
  • Histamine / metabolism*
  • Imidazoles / metabolism
  • In Vitro Techniques
  • Putrescine / metabolism*
  • Tissue Distribution

Substances

  • Aldehydes
  • Imidazoles
  • 4-aminobutyraldehyde
  • 1H-imidazole-4-acetaldehyde
  • Histamine
  • Aldehyde Dehydrogenase
  • Putrescine