Low Pre-Transplant Caveolin-1 Serum Concentrations Are Associated with Acute Cellular Tubulointerstitial Rejection in Kidney Transplantation

Molecules. 2021 Apr 30;26(9):2648. doi: 10.3390/molecules26092648.


Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. However, the strength of alloreactivity is biased by non-immunological factors such as ischemia reperfusion injury (IRI). Accordingly, protection from IRI could be favorable in terms of limiting graft rejection. Caveolin-1 (Cav-1) is part of the cell membrane and an important regulator of intracellular signaling. Cav-1 has been demonstrated to limit IRI and to promote the survival of a variety of cell types including renal cells under stress conditions. Accordingly, Cav-1 could also play a role in limiting anti-graft immune responses. Here, we evaluated a possible association between pre-transplant serum concentrations of Cav-1 and the occurrence of rejection during follow-up in a pilot study. Therefore, Cav-1-serum concentrations were analyzed in 91 patients at the time of kidney transplantation and compared to the incidence of acute and chronic rejection. Higher Cav-1 levels were associated with lower occurrence of acute cellular tubulointerstitial rejection episodes.

Keywords: Caveolin-1; graft rejection; ischemia and reperfusion injury (IRI); kidney transplantation.

MeSH terms

  • Adult
  • Aged
  • Biomarkers
  • Caveolin 1 / blood*
  • Female
  • Graft Rejection / blood*
  • Graft Rejection / diagnosis
  • Graft Rejection / mortality
  • Humans
  • Kaplan-Meier Estimate
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Nephritis, Interstitial / blood*
  • Nephritis, Interstitial / diagnosis
  • Nephritis, Interstitial / etiology*
  • Nephritis, Interstitial / mortality
  • Perioperative Period
  • Prognosis
  • Reperfusion Injury / diagnosis
  • Reperfusion Injury / etiology
  • Reperfusion Injury / metabolism


  • Biomarkers
  • Caveolin 1