Role of fibronectin in diagnosing bacterial infection in infancy

Am J Dis Child. 1988 Aug;142(8):884-7. doi: 10.1001/archpedi.1988.02150080090031.


Plasma fibronectin levels and complete blood cell counts were assessed prospectively among 100 infants less than 3 months of age with the provisional diagnosis of "possible sepsis". Seven of the ten infants with culture-proved bacteremia, meningitis, or urinary tract infection had low plasma fibronectin levels as did 12 (13%) of 90 infants with superficial or no documented bacterial infection. The positive predictive value of a low plasma fibronectin level in conjunction with leukocytosis and elevated band ratio for discriminating serious bacterial infection was 71%. Normal white blood cell counts or fibronectin level alone or in combination predicted the absence of serious bacterial infection with an accuracy of at least 94%. Plasma fibronectin determination provides a useful adjunct to the complete blood cell count for the rapid evaluation of extent of illness in young infants with possible sepsis.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Infections / blood
  • Bacterial Infections / diagnosis*
  • Fibronectins / blood*
  • Humans
  • Immunoassay
  • Infant
  • Infant, Newborn
  • Meningitis / blood
  • Meningitis / diagnosis
  • Nephelometry and Turbidimetry
  • Prospective Studies
  • Sepsis / blood
  • Sepsis / diagnosis
  • Urinary Tract Infections / blood
  • Urinary Tract Infections / diagnosis


  • Fibronectins