Plasma exosomes induce inflammatory immune response in patients with acute myocardial infarction

Arch Physiol Biochem. 2021 May 5;1-9. doi: 10.1080/13813455.2021.1912102. Online ahead of print.

Abstract

Exosomes are a kind of nanoscale extracellular vesicles with diameters of 30-100 nm and act as intracellular communication vehicles to influence cellular activities. Emerging pieces of evidence have indicated that exosomes play important roles in inflammation. However, the biological roles of plasma exosomes in acute myocardial infarction (AMI) patients have remained largely unexplored. In the current study, we found the plasma exosome levels were notably increased in patients with AMI in comparison with healthy controls (HCs), and AMI exosomes could induce endothelial cell injury. Furthermore, our data demonstrated that AMI exosomes triggered a pro-inflammatory immune response, at least partly depending on the activation of the NF-ĸB signalling. Together, AMI exosomes have pro-inflammatory properties and play a significant role in inflammation in AMI patients.

Keywords: Exosomes; NF-ĸB signalling; acute myocardial infarction; inflammatory immune response.