Treatment of uncomplicated gonorrhea with single-dose imipenem-cilastatin

M S Verdon; F N Judson; J M Ehret; C J Root; E W Hook 3rd; W M McCormack; C A Frances; K Draft; J W Shands; H H Handsfield

doi:10.1128/AAC.32.5.773

Treatment of uncomplicated gonorrhea with single-dose imipenem-cilastatin

Antimicrob Agents Chemother. 1988 May;32(5):773-4. doi: 10.1128/AAC.32.5.773.

Authors

M S Verdon¹, F N Judson, J M Ehret, C J Root, E W Hook 3rd, W M McCormack, C A Frances, K Draft, J W Shands, H H Handsfield

Affiliation

¹ Department of Medicine, University of Washington School of Medicine, Seattle 98104.

Abstract

Single 500-mg intramuscular doses of imipenem-cilastatin cured 116 (95%) of 122 men and 9 of 9 women with uncomplicated gonorrhea due to beta-lactamase-negative Neisseria gonorrhoeae. Most co-existing Chlamydia trachomatis infections persisted. Imipenem-cilastatin is effective for uncomplicated gonorrhea in men but has no advantages over other available regimens.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / therapeutic use*
Chlamydia Infections / complications
Chlamydia Infections / drug therapy
Chlamydia trachomatis
Cilastatin
Cilastatin, Imipenem Drug Combination
Cyclopropanes / administration & dosage
Cyclopropanes / therapeutic use
Drug Combinations / administration & dosage
Drug Combinations / therapeutic use
Female
Gonorrhea / complications
Gonorrhea / drug therapy*
Humans
Imipenem
Injections, Intramuscular
Male
Thienamycins / administration & dosage
Thienamycins / therapeutic use

Substances

Anti-Bacterial Agents
Cyclopropanes
Drug Combinations
Thienamycins
Cilastatin
Imipenem
Cilastatin, Imipenem Drug Combination