Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia

Can J Physiol Pharmacol. 2021 Oct;99(10):1112-1113. doi: 10.1139/cjpp-2021-0143. Epub 2021 May 5.

Abstract

Obstructive sleep apnea (OSA) is a chronic condition characterized by chronic intermittent hypoxia (IH) and is associated with cardiovascular (CVD) and chronic kidney diseases (CKD). Patients with OSA have increased biomarkers of aging such as telomere shortening. We used PCR to report shortened telomere lengths in aortic and renal tissues from mice exposed to 8 weeks of IH. Our data indicate that IH, a hallmark of OSA, accelerates vascular and renal aging that may contribute to OSA-induced CVD and CKD.

Keywords: apnée du sommeil; hypoxie intermittente; intermittent hypoxia; mice; renal; rénal; sleep apnea; souris; telomeres; télomères.

MeSH terms

  • Animals
  • Aorta / metabolism
  • Aorta / pathology*
  • Disease Models, Animal
  • Hypoxia / physiopathology*
  • Kidney / metabolism
  • Kidney / pathology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Stress
  • Telomere Shortening*