Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome

Comput Math Methods Med. 2021 Apr 15:2021:5587412. doi: 10.1155/2021/5587412. eCollection 2021.

Abstract

MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated that miR-188-3p might have a rare function of upregulating its targeted expression. This discovery will increase our understanding of the pathology of PCOS and provide new targets for treatment strategies.

MeSH terms

  • Adipogenesis / genetics
  • Computational Biology
  • Databases, Nucleic Acid
  • Female
  • Gene Expression Profiling
  • Gene Regulatory Networks
  • Granulosa Cells / metabolism*
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Polycystic Ovary Syndrome / genetics*
  • Polycystic Ovary Syndrome / metabolism
  • Signal Transduction / genetics
  • Up-Regulation

Substances

  • MIRN188 microRNA, human
  • MicroRNAs