Responsive neurostimulation for focal motor status epilepticus

Ann Clin Transl Neurol. 2021 Jun;8(6):1353-1361. doi: 10.1002/acn3.51318. Epub 2021 May 6.


No clear evidence-based treatment paradigm currently exists for refractory and super-refractory status epilepticus, which can result in significant mortality and morbidity. While patients are typically treated with antiepileptic drugs and anesthetics, neurosurgical neuromodulation techniques can also be considered. We present a novel case in which responsive neurostimulation was used to effectively treat a patient who had developed super-refractory status epilepticus, later consistent with epilepsia partialis continua, that was refractory to antiepileptic drugs, immunomodulatory therapies, and transcranial magnetic stimulation. This case demonstrates how regional therapy provided by responsive neurostimulation can be effective in treating super-refractory status epilepticus through neuromodulation of seizure networks.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Resistant Epilepsy / therapy*
  • Electric Stimulation Therapy*
  • Electrocorticography
  • Epilepsia Partialis Continua / therapy
  • Female
  • Humans
  • Implantable Neurostimulators*
  • Magnetic Resonance Imaging
  • Status Epilepticus / therapy*
  • Young Adult