Research progress on the regulatory role of microRNAs in spinal cord injury

Regen Med. 2021 May;16(5):465-476. doi: 10.2217/rme-2020-0125. Epub 2021 May 6.

Abstract

Spinal cord injury (SCI) is a severe CNS injury that results in abnormalities in, or loss of, motor, sensory and autonomic nervous function. miRNAs belong to a new class of noncoding RNA that regulates the production of proteins and biological function of cells by silencing translation or interfering with the expression of target mRNAs. Following SCI, miRNAs related to oxidative stress, inflammation, autophagy, apoptosis and many other secondary injuries are differentially expressed, and these miRNAs play an important role in the progression of secondary injuries after SCI. The purpose of this review is to elucidate the differential expression and functional roles of miRNAs after SCI, thus providing references for further research on miRNAs in SCI.

Keywords: exosome; lncRNA–miRNA network; microRNAs; spinal cord injury.