Aronia berry polyphenols have matrix-dependent effects on the gut microbiota

Xiaocao Liu; Derek A Martin; Jonathan C Valdez; Sailendharan Sudakaran; Federico Rey; Bradley W Bolling

doi:10.1016/j.foodchem.2021.129831

Aronia berry polyphenols have matrix-dependent effects on the gut microbiota

Food Chem. 2021 Oct 15:359:129831. doi: 10.1016/j.foodchem.2021.129831. Epub 2021 Apr 20.

Authors

Xiaocao Liu¹, Derek A Martin², Jonathan C Valdez², Sailendharan Sudakaran³, Federico Rey⁴, Bradley W Bolling⁵

Affiliations

¹ College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; University of Wisconsin-Madison, Department of Food Science, 1605 Linden Dr., Madison, WI 53706, USA.
² University of Wisconsin-Madison, Department of Food Science, 1605 Linden Dr., Madison, WI 53706, USA.
³ University of Wisconsin-Madison, Wisconsin Institute for Discovery, 330 North Orchard St., Madison, WI 53715, USA.
⁴ University of Wisconsin-Madison, Department of Bacteriology, 1550 Linden Dr., Madison, WI 53706, USA.
⁵ University of Wisconsin-Madison, Department of Food Science, 1605 Linden Dr., Madison, WI 53706, USA. Electronic address: bwbolling@wisc.edu.

PMID: 33957324
DOI: 10.1016/j.foodchem.2021.129831

Abstract

The objective of this study was to determine the extent that the aronia berry matrix affects gut microbiota composition, fecal short chain fatty acids (SCFAs), and colonic anthocyanins in healthy mice. C57BL/6J mice were fed AIN-93 M control diet (C) or C with whole aronia berry (AB), aronia extract (AE), or polyphenol-depleted AB (D) at the expense of cornstarch. After one week of feeding, AB and D increased fecal anthocyanins more than AE. Diets differentially affected SCFA and microbiota. AB fecal SCFA was associated with increased metabolism of succinate and pyruvate to butyrate. D increased acetic acid production, was associated with increased abundance of predicted genes for fermentation of carbohydrates to acetyl-coA. AB and D also increased predicted abundance of microbial catechol metabolism pathway I relative to C, which was attributed to enrichment of Lachnospiraceae. Therefore, the berry matrix impacts how aronia polyphenols interact with the gut microbiota in healthy mice.

Keywords: Anthocyanin; Aronia; Gut Microbiota; Lachnospiraceae; Polyphenol; Short Chain Fatty Acid.

MeSH terms

Animals
Colon / drug effects
Colon / microbiology
Feces / microbiology
Fruit / chemistry*
Gastrointestinal Microbiome / drug effects*
Male
Mice
Mice, Inbred C57BL
Photinia / chemistry*
Polyphenols / pharmacology*

Substances

Polyphenols