A comparative study of two preservative-free tear substitutes in the management of severe dry eye

Can J Ophthalmol. 1988 Jun;23(4):174-6.


Between mid-May and mid-July 1987 we performed a prospective crossover study of two unit-dose preservative-free artificial tear solutions, 1.4% polyvinyl alcohol (Refresh) and 0.1% sodium hyaluronate (Hylorin) in 14 female patients with severe dry eye syndrome. The patients were examined before treatment and after each of two trials with both products. A significant reduction in the mean score for dry-eye-induced keratitis (p = 0.001) and for mucous strands (p = 0.03) was observed following the second of two trials with sodium hyaluronate. A significant reduction in the mean score for burning and irritation was observed with both solutions (p = 0.009). We believe that the elimination of preservatives from artificial tear preparations may substantially reduce the iatrogenic effects of these frequently applied medications.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Child
  • Drug Evaluation
  • Female
  • Humans
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / therapeutic use*
  • Middle Aged
  • Ophthalmic Solutions
  • Polyvinyl Alcohol / administration & dosage
  • Polyvinyl Alcohol / therapeutic use*
  • Preservatives, Pharmaceutical
  • Prospective Studies
  • Tears
  • Xerophthalmia / drug therapy*


  • Ophthalmic Solutions
  • Preservatives, Pharmaceutical
  • Polyvinyl Alcohol
  • Hyaluronic Acid