Overcoming translational barriers in modeling macular degenerations

Nicholas David Nolan; Peter M J Quinn; Stephen H Tsang

doi:10.1016/j.stem.2021.04.015

Overcoming translational barriers in modeling macular degenerations

Cell Stem Cell. 2021 May 6;28(5):781-783. doi: 10.1016/j.stem.2021.04.015.

Authors

Nicholas David Nolan¹, Peter M J Quinn², Stephen H Tsang³

Affiliations

¹ Jonas Children's Vision Care, Department of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA; Department of Biomedical Engineering, Columbia University, New York, NY, USA.
² Jonas Children's Vision Care, Department of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA.
³ Jonas Children's Vision Care, Department of Ophthalmology, New York-Presbyterian Hospital, New York, NY, USA; Department of Pathology & Cell Biology, Institute of Human Nutrition, and Columbia Stem Cell Initiative, New York, NY, USA. Electronic address: sht2@cumc.columbia.edu.

PMID: 33961756
DOI: 10.1016/j.stem.2021.04.015

Abstract

Advances in tissue mimetics are paving the way for interrogating both the pathobiology of human disease and innovative therapeutic paradigms. In this issue of Cell Stem Cell, Manian et al. (2021) develop a novel iPSC-derived retinal pigment epithelium (RPE)-choriocapillaris (CC) complex that recapitulates key features of macular degenerations.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

Abstract

Publication types

Grant support