RNA reports breaking news from mitochondria

Nimesha Tadepalle; Gerald S Shadel

doi:10.1016/j.molcel.2021.04.005

RNA reports breaking news from mitochondria

Mol Cell. 2021 May 6;81(9):1863-1865. doi: 10.1016/j.molcel.2021.04.005.

Authors

Nimesha Tadepalle¹, Gerald S Shadel²

Affiliations

¹ Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
² Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gshadel@salk.edu.

PMID: 33961775
DOI: 10.1016/j.molcel.2021.04.005

Abstract

Using mitochondria-targeted TALENS and ionizing radiation, consequences of mtDNA double-strand (ds) breaks were investigated by Tigano et al. (2021) who uncovered mtRNA as a retrograde second messenger of this form of mtDNA stress that activates the RIG-I/MAVS innate immune signaling pathway.

Publication types

Comment

MeSH terms

Cell Nucleus
DNA, Mitochondrial*
Immunity, Innate
Mitochondria / genetics
RNA* / genetics

Substances

DNA, Mitochondrial
RNA