Role of innate immunity in chemotherapy-induced peripheral neuropathy

Neurosci Lett. 2021 Jun 11;755:135941. doi: 10.1016/j.neulet.2021.135941. Epub 2021 May 4.


It has become increasingly clear that the innate immune system plays an essential role in the generation of many types of neuropathic pain including that which accompanies cancer treatment. In this article we review current findings of the role of the innate immune system in contributing to cancer treatment pain at the distal endings of peripheral nerve, in the nerve trunk, in the dorsal root ganglion and in the spinal dorsal horn.

Keywords: Bortezomib; Macrophage; Oxaliplatin; Paclitaxel; TLR4.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Ganglia, Spinal / drug effects
  • Ganglia, Spinal / immunology
  • Humans
  • Immunity, Innate / drug effects
  • Immunity, Innate / immunology*
  • Neuralgia / chemically induced*
  • Neuralgia / immunology*
  • Neuralgia / pathology
  • Spinal Cord Dorsal Horn / drug effects
  • Spinal Cord Dorsal Horn / immunology


  • Antineoplastic Agents