Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review

Curr Res Transl Med. 2021 Jul;69(3):103295. doi: 10.1016/j.retram.2021.103295. Epub 2021 May 4.


Chronic myeloid leukemia (CML) is a myeloproliferative disease that results from the BCR-ABL gene-induced transformation of a primitive hematopoietic cell. This disease has been extensively studied, and, as a result, a very effective therapy has been developed: the tyrosine kinase inhibitors. Although, there is a significant knowledge about the intrinsic biology of CML cells, alterations in their bone marrow microenvironment are not yet completely understood. In this concise review, we summarized recent findings on the composition and function of the bone marrow microenvironment in CML, and their importance in the progression of the disease and treatment resistance.

Keywords: Chronic Myeloid Leukemia; Hematopoietic Stem Cells; Leukemia; Microenvironment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Marrow
  • Fusion Proteins, bcr-abl* / genetics
  • Hematopoietic Stem Cells
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / genetics
  • Tumor Microenvironment


  • Fusion Proteins, bcr-abl